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June 6, 1977

Small Cell Bronchogenic CarcinomaA Prolonged Remission Following Chemotherapy

JAMA. 1977;237(23):2528. doi:10.1001/jama.1977.03270500080037

CONSIDERABLE progress has been made in the treatment of small cell bronchogenic carcinoma. Using chemotherapy with or without radiation therapy, objective tumor regression is noted in 40% to 90% of treated patients.1,2 Despite these high response rates, the median survival time of affected persons is still measured in months1; prolonged, diseasefree survival following chemotherapy has not been observed. This report is of interest, therefore, since it concerns a patient with small cell bronchogenic carcinoma who was treated only with chemotherapy and who is now free of clinical evidence of tumor more than 24 months after treatment was discontinued.

Report of a Case  A 65-year-old man had dyspnea and a 10% weight loss. Chest x-ray film showed atelectasis of the left lung. Bronchoscopy disclosed left vocal cord paralysis and a mass that obstructed the left mainstem bronchus. Biopsy specimen of this mass, bronchial washings, and results of sputum cytologic