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June 13, 1977

Phenytoin Hypersensitivity-Reply

JAMA. 1977;237(24):2601. doi:10.1001/jama.1977.03270510022005

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In Reply.—  Dr Wilensky is correct that we must always be careful in assigning a cause-effect relationship to one drug when a patient is also receiving another drug. However, the clinical syndrome of the patient we reported was characteristic of the commonly occurring reaction to phenytoin except for the transient renal failure. We considered the possibility that phenobarbitol (which structurally resembles phenytoin) could be implicated in this syndrome, but did not believe that a test dose or injection was warranted.