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April 8, 1974

Trephine Drill Biopsy of the Lung: Cleveland Clinic Experience

Author Affiliations

From the departments of pulmonary disease and pathology, the Cleveland Clinic Foundation, and the Cleveland Clinic Educational Foundation.; Read by Dr. VanOrdstrand as a Chairman's Address at the Section on Diseases of the Chest at the AMA Annual Convention, New York, June 25, 1973.

JAMA. 1974;228(2):189-191. doi:10.1001/jama.1974.03230270033021

One hundred thirteen biopsies were performed with use of a high-speed drill in 100 patients with diffuse lung disease. Adequate lung tissue was obtained in 70% of the biopsies. Pneumothorax resulted in 40% of the biopsies, but intubation treatment was required in only 7%. Hemoptysis occurred in 8%, pleuritic chest pain in 17%, and subcutaneous emphysema in 4%.

Most of the biopsies in our patients were office procedures, since our offices are a part of the hospital complex, but when the patient has advanced pulmonary function impairment, hospitalization is preferred for the trephine biopsy procedure. Trephine lung biopsy is a simple, useful, and relatively inexpensive procedure. Serious complications are infrequent. (JAMA 228:189-191, 1974)