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June 13, 1977

Intoxication Caused by Interaction of Chloramphenicol and Phenytoin

JAMA. 1977;237(24):2630-2631. doi:10.1001/jama.1977.03270510052024

A patient with a brain tumor and seizures who was receiving maintenance doses of phenytoin was given chloramphenicol on three occasions. Her neurological status was both complicated and obscured by the reoccurrence of phenytoin intoxication. Retrospective drug analysis showed a marked elevation of serum concentrations of phenytoin during each course of chloramphenicol.

(JAMA 237:2630-2631, 1977)