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June 20, 1977

Re: Persistence of Treponema pallidum Following Penicillin G Therapy

Author Affiliations

Venereal Disease Control Division Center for Disease Control Atlanta

JAMA. 1977;237(25):2719. doi:10.1001/jama.1977.03270520029008

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To the Editor.—  There are several errors in Dr Tramont's article entitled "Persistence of Treponema pallidum Following Penicillin G Therapy," (236: 2206, 1976). The author states that "in two adult patients, T pallidum was isolated from the CSF despite the fact that each received currently recommended amounts of penicillin G benzathine for secondary and neurosyphilis, respectively." However, the second case report describes isolation of T pallidum from CSF obtained before the patient received any penicillin. The author also states that this patient was later treated with "20 million units aqueous penicillin G benzathine, administered intravenously daily for three weeks." The benzathine salt of penicillin G should only be given intramuscularly. We feel these points need explanation.