[Skip to Content]
[Skip to Content Landing]
April 27, 1970

Amniographic Diagnosis of Trophoblastic Disease

Author Affiliations

Washington, DC

JAMA. 1970;212(4):630. doi:10.1001/jama.1970.03170170074032

To the Editor.—  The importance of early diagnosis of trophoblastic tumors, in order to prevent a drastic outcome, is stressed by Hsu in a review of a large series of cases of trophoblastic disease.1 Nevertheless, difficulties in the diagnosis of molar pregnancy by available clinical means and laboratory methods are frequently emphasized.2 It is natural, therefore, that with the introduction of aqueous contrast media, and acceptance of amniocentesis, there is a renewed interest in amniography for diagnosis of hydatid mole. Menees et al first employed amniography in 1930 for placental localization.3 Torres and Pelegrina,4 Goldstein and Reid,5 and others6 described a method which utilized a radiologic technique and which yielded definitive diagnosis in such cases. The following cases afforded the opportunity for corroborative study.

Report of a Case.—Case 1.—  A 19-year-old primigravida was admitted because of vaginal bleeding following a period of