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May 11, 1970

Coronary-Prone Individuals (Type A Behavior Pattern)Some Biochemical Characteristics

Author Affiliations

From the Harold Brunn Institute (Drs. Friedman, Byers, and Roseman) and the Department of Clinical Pathology (Dr. Elevitch), Mount Zion Hospital and Medical Center, San Francisco.

JAMA. 1970;212(6):1030-1037. doi:10.1001/jama.1970.03170190046006

Studies of the plasma triglyceride, free fatty acids, cholesterol, glucose, uric acid, cortisol, insulin, growth hormone, and thyroxine values of relatively "coronary-prone" (behavior type A) and relatively coronary "resistant" (behavior type B) subjects were performed. The group of coronary-prone subjects not only exhibited abnormally high plasma triglyceride (both before and after fat feeding) and cholesterol values but also a hyperinsulinemic response to a glucose challenge. There was also suggestive evidence of a decreased content of growth hormone in the plasma of the same coronary-prone subjects. Plasma levels of free fatty acids, uric acid, glucose, cortisol, and thyroxine, however, were not elevated in these same subjects.