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April 29, 1974

Clofibrate Treatment of Diabetes Insipidus

Author Affiliations

S.S.K. The Istanbul Hospital Istanbul, Turkey

JAMA. 1974;228(5):567. doi:10.1001/jama.1974.03230300015010

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To the Editor.—  I would like to add my experience in treating idiopathic diabetes insipidus to that of Drs. Hamuth and Gelb (224:1041, 1973).

Report of a Case.—  A 19-year-old white man was first seen in November 1973 with a history of polydipsia for two years. The diagnosis of idiopathic diabetes insipidus was established and he responded well to treatment with vasopressin (Pitressin tannate in oil) as well as the other antidiuretic drugs, until two months prior to his visit. At this time, polydipsia and polyuria (7 to 8 liters/day) persisted despite daily injections of vasopressin.An intravenous pyelogram showed marked dilation of the ureters. A skull roentgenogram showed a normal sella turcica with minimal calcification of the pineal body. Creatinine clearance was 121.5 ml. The blood pressure was 135/85 mm Hg, and blood urea nitrogen was 20 mg/100 ml. Prior to treatment, urine volume had been 420 ml/hr (9