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April 29, 1974

Hypoproteinemia and Anemia in Infants With Cystic Fibrosis: A Presenting Symptom Complex Often Misdiagnosed

Author Affiliations

From the Department of Pediatrics, University of Michigan, Ann Arbor. Dr. Lee is now with the Clinical Investigation Center, Oakland Naval Hospital, Oakland, Calif.

JAMA. 1974;228(5):585-588. doi:10.1001/jama.1974.03230300025022

Infants with cystic fibrosis occasionally may present with a symptom complex of anemia, hypoproteinemia, and edema. Case reports of seven infants between the ages of 1 to 4 months who developed these abnormalities indicate that in several instances the children's condition was misdiagnosed as milk-sensitivity or milk-allergy. Furthermore, their case histories verify that their hypoalbuminemia and anemia is nutritional and is corrected when a readily absorbed diet with a pancreatic-enzyme supplement is given. A retrospective review of feeding histories of 100 infants with cystic fibrosis, as well as these case reports, indicate that affected children who are breast-fed or fed with soy-based formulas are more likely to develop the syndrome.

(JAMA 228:585-588, 1974)