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July 11, 1977

Theophylline Concentrations in Asthmatic Patients: After Administration of Aminophylline

Author Affiliations

From the Division of Allergic Diseases and Internal Medicine (Drs Kordash and Van Dellen), and the Section of Clinical Chemistry (Dr McCall), Mayo Clinic and Foundation; and the Division of Allergy, Mayo Graduate School of Medicine, University of Minnesota (Dr Kordash), Rochester.

JAMA. 1977;238(2):139-141. doi:10.1001/jama.1977.03280020043021

To test the efficacy of using a weight-derived formula to determine aminophylline dosages, 50 patients hospitalized for treatment of severe asthma were given intravenous aminophylline infusions at a rate of 0.9 mg/kg/hr to a maximum dosage of 1,500 mg/24 hr. Serum theophylline determinations done 12 to 96 hours after institution of this therapy showed levels greater than 20 mg/liter in 34% of these patients. Reliance on weight-derived formulas can be dangerous.

(JAMA 238:139-141, 1977)