To test the efficacy of using a weight-derived formula to determine aminophylline dosages, 50 patients hospitalized for treatment of severe asthma were given intravenous aminophylline infusions at a rate of 0.9 mg/kg/hr to a maximum dosage of 1,500 mg/24 hr. Serum theophylline determinations done 12 to 96 hours after institution of this therapy showed levels greater than 20 mg/liter in 34% of these patients. Reliance on weight-derived formulas can be dangerous.
(JAMA 238:139-141, 1977)
Kordash TR, Van Dellen RG, McCall JT. Theophylline Concentrations in Asthmatic Patients: After Administration of Aminophylline. JAMA. 1977;238(2):139–141. doi:10.1001/jama.1977.03280020043021
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