A double-blind study was undertaken to evaluate the efficacy of clindamycin hydrochloride hydrate as compared with tetracycline hydrochloride and placebo in the treatment of Mycoplasma pneumoniae. Thirty-two young adult men were studied. Clindamycin failed to cause defervescence or roentgenographic resolution more promptly than placebo. Tetracycline was associated with a shortening of the duration of fever.
(JAMA 228:729-731, 1974)
Smilack JD, Burgin WW, Moore WL, Sanford JP. Mycoplasma pneumoniae Pneumonia and Clindamycin Therapy: Failure to Demonstrate Efficacy. JAMA. 1974;228(6):729–731. doi:10.1001/jama.1974.03230310039025
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