Prazosin hydrochloride is an orally administered vasodilator that recently became available for the treatment of hypertension. It causes less tachycardia than hydralazine but may produce orthostatic hypotension, particularly after the initial dose. The role of prazosin in therapy is limited because of the risk of a first-dose syncopal reaction, and it appears to be indicated primarily in patients who cannot tolerate hydralazine hydrochloride or sympathetic depressant drugs. Like other antihypertensive agents, prazosin should be given with a diuretic.
(JAMA 238:157-159, 1977)
Kosman ME. Evaluation of a New Antihypertensive AgentPrazosin Hydrochloride (Minipress). JAMA. 1977;238(2):157–159. doi:10.1001/jama.1977.03280020061029
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