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July 18, 1977

Medical News

JAMA. 1977;238(3):201-207. doi:10.1001/jama.1977.03280030009001

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Kidney transplant recipients do well on alternate-day steroid regimen  Despite the often serious side effects of long-term daily steroid therapy, it continues to be used to prevent rejection of transplanted kidneys. A recent report suggests that it may be possible to reduce the unwanted effects and still protect the kidney by weaning the patient gradually to a lower steroid dosage every other day.Richard L. Burleson, MD, admitted during the recent meeting of the American Society of Transplant Surgeons in Chicago that previous investigators of alternate-day steroid therapy have found the risk of rejection unacceptably high. In these studies, however, alternate-day treatment was begun to lessen steroid side effects. In his series, the tapering-off process was planned from the outset, and was offered to all patients who had stable renal function while receiving conventional steroid therapy for six months following transplant or nine months after the most recent rejection