Malignant mesenchymoma developed in an 18-year-old patient with phenytoin-associated cleft lip and palate. Although these conditions may be related by chance, the possibility of transplacental carcinogenesis by phenytoin should be considered, especially since neuroblastoma was reported recently in two children with phenytoin-induced malformations. Following combination chemotherapy for metastases, the patient experienced a 7-year disease-free interval, which is consistent with recent improvements in the treatment of soft-tissue sarcomas.
(JAMA 238:334-335, 1977)
Blattner WA, Henson DE, Young RC, Fraumeni JF. Malignant Mesenchymoma and Birth DefectsPrenatal Exposure to Phenytoin. JAMA. 1977;238(4):334–335. doi:10.1001/jama.1977.03280040054022
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: