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July 25, 1977

Treatment of Schizophrenia: Progress and Prospects

Author Affiliations

Temple University Philadelphia

JAMA. 1977;238(4):349-350. doi:10.1001/jama.1977.03280040069035

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


With medical models of schizophrenias and with a variety of treatment approaches, all the complexity and diversity must be summarized from time to time to permit the clinicians to "keep up," and maintain perspective.

The book consists of six parts: "Models of Schizophrenia"; "Psychopharmacologic Approaches"; "Individual Psychotherapy"; "Small Group Approaches"; "Milieu and Social Approaches"; and finally an overview. Each part has an introduction, which summarizes and focuses highlights from the respective chapters.

Zubin's model of schizophrenia proposes stress, vulnerability, and symptoms if a threshold is reached. At any level a variety of factors exert influence. The editors introduce this as a "global" model, although it hardly seems so to me. Meanwhile, Kety presents a neurochemical model admitting many etiologic factors, but finally influencing the brain and its programming via catecholamine transmitters and dopaminergic systems. Mandel gives a biochemical model that considers a variety of adaptive mechanisms that affect neurotransmitter systems.