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June 1, 1970

Salicylates and Bleeding

Author Affiliations

Marquette School of Medicine Milwaukee

JAMA. 1970;212(9):1524. doi:10.1001/jama.1970.03170220078021

To the Editor.—  In 1966 I presented experimental and clinical evidence that acetylsalicylic acid increases the Duke bleeding time and that this drug also accentuates the bleeding tendency in many patients with bleeding states. In addition, I described my aspirin tolerance test whereby patients sensitive to this drug can be readily detected.1 Increasing reports are now appearing in the medical literature confirming my observation but, as so often happens, when the pendulum swings, it can overshoot its rational arc. Thus, under medical news (211:1108, 1970), the advisability of making aspirin a prescription drug is considered because "the public knows too little about dangers of indiscriminate aspirin usage." It happens that in the same issue under questions and answers (211:1195, 1970), the answer given to the inquiry on the control of nasal hemorrhage in the Rendu-Osler-Weber syndrome, the avoidance of aspirin was not even mentioned. Yet, in 1967