The relative effectiveness of alkali, urea, and invert sugar, administered intravenously in the treatment of the painful, febrile crisis of sickle cell anemia was compared in a cooperative study between Bowman Gray, Duke University, Emory University, and University of Tennessee schools of medicine. Because of the highly subjective nature of the crisis, patients were treated and evaluated over a 48-hour period following a carefully designed, doubleblind protocol. The type of medication used for each patient was predetermined using a table of random numbers. Neither urea nor alkali administration was found to be superior to invert sugar alone in shortening the crisis episodes.
(JAMA 228:1120-1124, 1974)
Clinical Trials of Therapy for Sickle Cell Vaso-occlusive Crises: Cooperative Urea Trials Group. JAMA. 1974;228(9):1120–1124. doi:10.1001/jama.1974.03230340022022
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