[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 34.232.62.209. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
May 27, 1974

Clinical Trials of Therapy for Sickle Cell Vaso-occlusive Crises: Cooperative Urea Trials Group

JAMA. 1974;228(9):1120-1124. doi:10.1001/jama.1974.03230340022022
Abstract

The relative effectiveness of alkali, urea, and invert sugar, administered intravenously in the treatment of the painful, febrile crisis of sickle cell anemia was compared in a cooperative study between Bowman Gray, Duke University, Emory University, and University of Tennessee schools of medicine. Because of the highly subjective nature of the crisis, patients were treated and evaluated over a 48-hour period following a carefully designed, doubleblind protocol. The type of medication used for each patient was predetermined using a table of random numbers. Neither urea nor alkali administration was found to be superior to invert sugar alone in shortening the crisis episodes.

(JAMA 228:1120-1124, 1974)

×