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May 27, 1974

Renal Transplantation Between Adults and Children: Differences in Renal Growth

Author Affiliations

From the Department of Surgery, Division of Urology, University of Michigan Medical Center, Ann Arbor. Dr. Silber is now with the Department of Surgery, University of Melbourne, Royal Melbourne Hospital, Australia.

JAMA. 1974;228(9):1143-1145. doi:10.1001/jama.1974.03230340045031

There is an impressive but purely compensatory growth response of the child's kidney transplanted into the uremic adult, but no hypertrophy or hypotrophy of the adult's kidney in the uremic child.

Two separate types of renal growth seem to occur. Compensatory hypertrophic growth is a rapid reversible response to a functional nephron deficit. Obligatory growth occurs as one grows up, and is not reversible.

(JAMA 228:1143-1145, 1974)