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Fitting the antibiotic to the infecting organism occupies most of the attention of the eight contributors to Infectious Diseases. First they discuss the penicillins (they prefer to give only one type of penicillin at a time); then they take up most of the other commercially available antimicrobial drugs. They provide alternative treatments for drug-allergic patients and special dosage schedules for the patient with a damaged liver or kidneys.
Whenever practicable, they treat each patient's infection with a single, preferably bactericidal, antibiotic, and combine antibiotics only in special cases such as enterococcal or abacteremic endocarditis (they give penicillin and streptomycin for at least six weeks); for Pseudomonas septicemia, they recommend gentamicin and carbenicillin; for undefined sepsis, they start treatment with gentamicin and ampicillin or oxacillin; and for advanced tuberculosis, they initiate treatment with isoniazid, ethambutol, and streptomycin.
Their discussions also include the reports of persisting treponemas in treated patients with late
Greenberg HB. Infectious Diseases. JAMA. 1974;228(9):1167. doi:10.1001/jama.1974.03230340065044
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