This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.
To the Editor.—
We are gratified that Uddin et al (227:1405, 1974) have found the automated dithionite test (Clin Chem 17:1033, 1971) so reliable in sickle cell hemoglobin screening.Because of the closing caveat about screening civilian populations, emphasis on several points is offered.The use of the automated dithionite test (ADT) as the initial method of screening, and the reservation of hemoglobin electrophoresis (HE) for those cases that are ADT-positive or that require genetic counseling, is an eminently satisfactory procedure, yielding requisite data at lowest cost.Not all newly found cases of hemoglobin S will require or demand genetic counseling; when the ADT gives positive findings, the HE should be performed on such specimens in that sequence to get the essential data. Electrophoresis does not need to be done on all specimens in any given test population.Exaggerated preoccupation with hemoglobin C has led to the expensive and redundant
Nalbandian RM, Camp FR, Henry RL. Sickle Cell Screening. JAMA. 1974;228(10):1227. doi:10.1001/jama.1974.03230350017007
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: