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June 3, 1974

Is It All IgG?

JAMA. 1974;228(10):1228. doi:10.1001/jama.1974.03230350018011

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To the Editor.—  The newborn infant is protected from infection for many months by maternal IgG. This is the accepted version. We have come to question this. IgG does not seem the answer for the complete protection with which the young are blessed. They are not only seemingly protected against bacteria, but also viruses and fungi. IgG just does not seem to be able to do all of this.Oral thrush and diaper rash typical of candidiasis have been seen with greater frequency in our practice during the past few years. There is a pattern with these cases—usually the mother has had symptoms of a candidiasis, vaginal discharge before birth, itchy eyes, itchy ears, coated tongue, and symptoms of a pathogenic body mold. Often the father has signs and symptoms; then, the whole family is a problem. Is this a deficit of cell-mediated immunity secondary to transfer-factor inadequacy?Therefore, are