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Article
August 15, 1977

Electron Microscopy of Urinary Sediment in Fabry's Disease

JAMA. 1977;238(7):580-581. doi:10.1001/jama.1977.03280070020008
Abstract

To the Editor.—  Authors of the CLINICAL NOTE "Urinary Ultrastructural Findings in Fabry Disease" (237:1121, 1977), Sheila M. Katz, MD, and Patricia J. Lyons, MD, concluded that electron microscopic examination of the urine may be useful in the diagnosis of Fabry's disease with renal involvement.In 1970 Duncan1 reported three cases of Fabry's disease studied by electron microscopy. In two of his cases urinary sediment showed the presence of laminated, round osmiophilic bodies, similar to those found in renal foam cells. Duncan suggested that electron microscopic studies of urine for osmiophilic bodies may be of use as an indication of glomerular recovery in a follow-up of treated patients.Recently electron microscopic studies of gingival mucosa have also been used in the diagnosis of Fabry's disease. Osmiophilic bodies were found in endothelial, perithelial, fibroblastic, phagocytic, and epithelial cells of gingival mucosa of affected persons.2Early diagnosis of this interesting

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