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August 15, 1977

Serum Ferritin Level: Determinant of Iron Requirement in Hemodialysis Patients

Author Affiliations

From the Department of Medicine, Nephrology Division, Veterans Administration Hospital, Long Beach (Drs Mirahmadi, Winer, and Gorman); the University of California, Irvine (Drs Dabir-Vaziri and Rosen); and Bio-Science Laboratories, Van Nuys (Dr Paul and Mr Byer), Calif.

JAMA. 1977;238(7):601-603. doi:10.1001/jama.1977.03280070041020

Seventeen patients without renal failure and 14 patients receiving longterm hemodialysis were studied. Serum and bone marrow ferritin determinations were made at the time of bone marrow aspiration. A good correlation was found between serum ferritin levels and bone marrow iron stores, as well as between bone marrow ferritin levels and iron stores. Serum ferritin determinations appear to give an accurate estimation of bone marrow iron stores, thereby providing a reliable guide for iron replacement therapy and reducing the need for repeated bone marrow aspirations. Serum ferritin levels of less than 105 ng/ml suggest decreased iron stores, and values greater than 120 ng/ml indicate adequate or increased iron stores. Preliminary data also suggest that bone marrow ferritin determinations may be useful in quantitating bone marrow iron stores.

(JAMA 238:601-603, 1977)