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August 22, 1977

Quinidine-Induced Agranulocytosis

JAMA. 1977;238(8):884-886. doi:10.1001/jama.1977.03280090048022

In a 75-year-old man, agranulocytosis and septicemia developed after eight weeks of quinidine sulfate therapy. An IgG antibody requiring the presence of quinidine was shown by complement-dependent leukocytotoxicity and leukoagglutination reactions. The antibody did not cross-react with quinine and was active against WBCs obtained from normal subjects and from the patient himself.

(JAMA 238:884-886, 1977)