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August 22, 1977

Quinidine-Induced Agranulocytosis

Author Affiliations

From the Department of Medicine, University of Wisconsin Medical School (Drs Eisner, Carr, and MacKinney), and the William S. Middleton Veterans Administration Hospital (Drs Eisner and MacKinney), Madison.

JAMA. 1977;238(8):884-886. doi:10.1001/jama.1977.03280090048022

In a 75-year-old man, agranulocytosis and septicemia developed after eight weeks of quinidine sulfate therapy. An IgG antibody requiring the presence of quinidine was shown by complement-dependent leukocytotoxicity and leukoagglutination reactions. The antibody did not cross-react with quinine and was active against WBCs obtained from normal subjects and from the patient himself.

(JAMA 238:884-886, 1977)