In a 75-year-old man, agranulocytosis and septicemia developed after eight weeks of quinidine sulfate therapy. An IgG antibody requiring the presence of quinidine was shown by complement-dependent leukocytotoxicity and leukoagglutination reactions. The antibody did not cross-react with quinine and was active against WBCs obtained from normal subjects and from the patient himself.
(JAMA 238:884-886, 1977)
Eisner EV, Carr RM, MacKinney AA. Quinidine-Induced Agranulocytosis. JAMA. 1977;238(8):884–886. doi:10.1001/jama.1977.03280090048022
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: