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June 22, 1970

Improved Endoscopic Diagnosis of Gastroesophageal Malignancy: Combined Use of Direct Vision Brushing Cytology and Biopsy

Author Affiliations

From the Department of Medicine, University of Chicago Pritzker School of Medicine, Chicago.

JAMA. 1970;212(12):2086-2089. doi:10.1001/jama.1970.03170250042006

Modern endoscopic instruments for examination of the esophagus and stomach are constructed to allow diagnostic cytology by brushing and biopsy of lesions under direct vision. The conditions of all 26 patients with cancer of the upper gastrointestinal tract were correctly diagnosed by the combination of direct-vision brushing cytology and biopsy, while roentgenographic and endoscopic examination alone were successful in only 73.3% and 83.3% of the cases, respectively. Such instruments, therefore, provide a safe, convenient, and accurate method for the definitive, microscopical diagnosis of gastroesophageal malignancy. They are of special value in the correct identification of malignant gastric ulcers of benign gross appearance.