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August 29, 1977

Medical News

JAMA. 1977;238(9):927-932. doi:10.1001/jama.1977.03280100011001

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1977 World Rheumatism Year; reports given in San Francisco 

Mixed connective tissue disease: a separate entity?  Many of the clinical features of mixed connective tissue disease (MCTD) are used in identifying systemic lupus erythematosus (SLE), physicians were reminded recently at the International Congress of Rheumatology in San Francisco. But the question of whether or not MCTD can be separated from SLE or other connective tissue diseases remains unresolved.Clinical and laboratory manifestations of MCTD include Raynaud's phenomenon, esophageal dysfunction, pulmonary disease, and frequently sclerodactylia.Investigators from the University of Missouri and from Tokyo's Keio University said that when specifically sought, organ involvement is frequent, though often clinically inapparent. Decreased diffusion capacity (values from 30% to 70% of normal) is a hallmark of abnormal pulmonary function in the patients. Pulmonary involvement was present in 69% of 28 patients with MCTD radiological abnormalities. Serial studies of 14 such patients who received