To the Editor:—
The phenomenon of tumor-to-tumor metastasis, albeit infrequent, has been reported by a number of observers. Osterberg1 reviewed three previously reported cases, and added two: one of bronchial origin, the other probably of renal origin, both spreading to meningiomas.Best2 added a case of bronchogenic squamous carcinoma metastasizing to a meningioma. The synchronous occurrence of lymphosarcoma and adenocarcinoma with tumor-to-tumor metastasis was reported by Jernstrom and Murray3 in 1966; they reviewed the literature on cases of carcinoma associated with leukemia and lymphoma. The simultaneous occurrence of adenocarcinoma and leiomyosarcoma of the stomach was described by Sirsat and Sampat.4Coppola et al5 reported a case of coexisting lymphoma, gastric adenocarcinoma, amyloidosis, and monoclonal gammopathy.Sirsat and Shrikhande6 also noted two instances of collision between melanoma and squamous cell carcinoma in the oral cavity in 1966. More recently, Jones et al7 described the
Anlyan FH, Heinzen BR, Carras R. Metastasis of Tumor to Second Different Tumor: Collision Tumors. JAMA. 1970;212(12):2124. doi:10.1001/jama.1970.03170250078030
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