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June 24, 1974

Medical News

JAMA. 1974;228(13):1627-1635. doi:10.1001/jama.1974.03230380005002

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Treatment of pregnant mother corrects baby's metabolic defect  An inborn error in vitamin B12 metabolism has been successfully treated in utero by clinicians at Tufts University School of Medicine.When the B12 responsive form of methylmalonic acidemia was diagnosed in a fetus at 19 weeks gestation, massive doses of the vitamin were administered to the mother. Her urinary excretion of methylmalonic acid promptly decreased, instead of rising during those last weeks of pregnancy. She delivered a healthy, alert baby who is now 6 months old and of apparently normal intelligence.Mary G. Ampola, MD, an assistant professor of pediatrics at Tufts, discussed the case at a joint meeting of the American Pediatric Society, and the Society for Pediatric Research in Washington. Working with her are Maurice J. Mahoney, MD, Eiichi Nakamura, MD, PhD, and Kay Tanaka, MD, PhD, from Yale University's Department of Human Genetics.The mother first