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September 5, 1977

Insulin-Dependent Diabetes MellitusSudden Onset Following Hypophysectomy in an Acromegalic Patient

JAMA. 1977;238(10):1047-1048. doi:10.1001/jama.1977.03280110051022

A euglycemic woman with acromegaly contracted conspicuous hyperglycemia two hours following transphenoidal hypophysectomy. Insulin therapy was initiated and has by necessity been continued. The development in the immediate postoperative period of blood glucose levels ranging from 300 to 500 mg/dl was totally unexpected, as the levels on the preoperative oral glucose tolerance test were normal. No explanation for this sudden development of hyperglycemia is apparent. Therefore, frequent monitoring of the blood glucose level is necessary in all acromegalic patients following hypophysectomy, even if they are euglycemic prior to surgery.

(JAMA 238:1047-1048, 1977)