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July 1, 1974

Minimal Effective Dosage of Cromolyn

Author Affiliations

Marblehead, Mass

JAMA. 1974;229(1):22. doi:10.1001/jama.1974.03230390014003

To the Editor.—  Numerous studies have shown that cromolyn sodium is an effective antiasthmatic medicine when used prophylactically on a regular basis. Cromolyn inhibits the degranulation of sensitized mast cells that occurs after exposure to specific antigens, and inhibits the release of histamine and SRS-A. The manufacturers of cromolyn, and investigators, advise a starting dose of 20 mg (one capsule) four times a day by inhalation, for children 5 years old and over.1 The manufacturers' brochures state that "the dose for adults and children 5 and over is the contents of one Aarane capsule inhaled four times daily at regular intervals...." Dykes2 specifies the minimum dosage that is found effective. For this reason, the following case illustrates an important point.

Report of a Case.—  A 5-year-old white boy gave a three-year history of asthma, and had been wheezing almost daily for two years. His wheezing increased with exercise.