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July 1, 1974

Standardization of Immunoglobulin Determinations

Author Affiliations

St. Francis Hospital Hartford, Conn

JAMA. 1974;229(1):25. doi:10.1001/jama.1974.03230390017013

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To the Editor.—  In view of the up-to-date methods now readily available for the quantitative determinations of various immunoglobulins, Dr. J. I. Spector's article, "Juvenile Achlorhydric Pernicious Anemia With IgA Deficiency" (228:334, 1974), contains data that are somewhat confusing and perhaps misleading.Serum immunoelectrophoresis is primarily a qualitative test, at best only semiquantitative. Further, his data on the immunoglobulin values are not in conformity with those that are known more widely in the field of immunochemistry. It is unfortunate that immunoglobulins were not measured by more sensitive and precise methods such as single radial immunodiffusion or more preferably a nephelometric method, reporting their values in relation to more widely accepted and acknowledged normal ranges.In view of the fact that there is an international effort to standardize our expression of immunoglobulin levels based upon the assays performed with international reference preparation (WHO Expert Committee on Biological Standardization, WHO Tech Rep