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September 12, 1977

Male Pattern Alopecia Regrowth Following Topical Fluorouracil Therapy

JAMA. 1977;238(11):1149. doi:10.1001/jama.1977.03280120041009

To the Editor. —  We wish to report a patient thought to have male pattern baldness for ten years; he began to regrow terminal hair after his scalp was treated with fluorouracil for actinic keratosis.

Report of a Case.—  The patient is a 45-year-old man who had been bald in a frontoparietal distribution for ten years when seen on Sept 27, 1976, at the Dermatology Clinic, Brooke Army Medical Center. He had multiple actinic keratoses of the scalp and was treated with 2% fluorouracil (Efudex) solution followed in ten minutes with 0.5% triamcinolone acetonide cream daily.1 When seen on Oct 18, 1976, after 21 days of treatment, a confluent, brisk erythema and edema engulfed the scalp, nose, and temples. The fluorouracil therapy was discontinued, and the reaction subsided after three weeks of 0.5% triamcinolone therapy. The patient was not seen again until March 10, 1977, when he returned specifically