Immunofluorescent microscopy was performed on the clinically normal skin of 3 patients with infective endocarditis, 3 patients with bacteremia, and 6 normal subjects. Perivascular deposition of immunoglobulin and complement was demonstrated in two of the three patients with infective endocarditis and in none of the bacteremic or control subjects.
(JAMA 238:1163-1165, 1977)
Lowenstein MB, Urman JD, Abeles M, Weinstein A. Skin Immunofluorescence in Infective Endocarditis. JAMA. 1977;238(11):1163–1165. doi:10.1001/jama.1977.03280120055016
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