A relative increase in erythrocyte volume is observed in patients who have connective tissue diseases and who are treated with cyclophosphamide and azathioprine. Hemoglobin loss correlates with the magnitude of the volume increase.
(JAMA 229:180-181, 1974)
Klippel JH, Decker JL. Relative Macrocytosis in Cyclophosphamide and Azathioprine Therapy. JAMA. 1974;229(2):180–181. doi:10.1001/jama.1974.03230400042029
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