Recently, two infants with severe infections due to ampicillin-resistant strains of Haemophilus influenzae type B were treated at Children's Hospital National Medical Center. In both cases, it was necessary to change therapy to chloramphenicol. One patient with meningitis died while the second with bacteremia and pneumonia recovered. A survey of 60 recent isolates of H influenzae type B in the Washington community showed that 10% were ampicillin-resistant. The enzyme produced by these resistant strains was found to be a β-Iactamase. Careful appraisal is now necessary to decide whether ampicillin is the drug of choice as initial therapy in H influenzae meningitis in pediatric patients.
(JAMA 229:298-301, 1974)
Khan W, Ross S, Rodriguez W, Controni G, Saz AK. Haemophilus influenzae Type B Resistant to Ampicillin: A Report of Two Cases. JAMA. 1974;229(3):298–301. doi:10.1001/jama.1974.03230410022016
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: