Long-term, continuous follow-up of hyperactive children under treatment was instituted with the use of a monthly, quantified teachers student rating scale and the insertion of a placebo month per year. All subjects receiving medication had previously been shown to be benefited by stimulants. After two years of follow-up with 42 subjects, 26% were able to function well without drugs; 40% were still benefited by medication. Physicians treating such children should periodically try drug-free periods during the school year.
(JAMA 229:316-317, 1974)
Sleator EK, von Neumann A, Sprague RL. Hyperactive Children: A Continuous Long-Term Placebo-Controlled Follow-Up. JAMA. 1974;229(3):316–317. doi:10.1001/jama.1974.03230410040022
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