A prospective study was carried out to discern the outcome of pregnancy and distribution of birth weights of infants delivered of 85 women with sickle cell trait (AS) compared with a control group of 85 women with normal hemoglobin (AA) who were matched for race, age, parity, and sex of offspring.
The distribution of birth weight of offspring of primiparous and multiparous women and the proportion of low-birth-weight infants did not differ significantly between infants born to mothers with AS and those in the control group. Similarly, there was no statistically significant difference between the birth weight of infants born to primipara or multipara. Also, the overall incidence of complications among women with AS did not differ from the incidence in the control group.
These findings do not support previous reports that there may be definable pathologic correlates of childbearing in women with AS.
(JAMA 238:1392-1394, 1977)
Blattner P, Dar H, Nitowsky HM. Pregnancy Outcome in Women With Sickle Cell Trait. JAMA. 1977;238(13):1392–1394. doi:10.1001/jama.1977.03280140070025
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