[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
October 3, 1977

Metastatic Bone Disease

Author Affiliations

Southern California Permanente Medical Group Panorama City

JAMA. 1977;238(14):1503. doi:10.1001/jama.1977.03280150073031

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


To the Editor.—  In "Distribution Pattern of Metastatic Bone Disease" (237:2504-2506, 1977), there is a misleading item in the results that demands mention: not one case of femoral metastasis in breast carcinoma. Tell that to the unfortunate women who have experienced the dreaded complication of femoral fracture.There must be a lesson to be learned, perhaps that the femur is not scintigraphically involved early in the course of bone metastasis, where in this study there was a mean of only 3.8 lesions per patient.To test this hypothesis, we analyzed 68 consecutive cases of breast cancer with positive bone scintigrams. Fourteen (21%) of these women had a total of 16 femoral lesions, which was 3.8% of all the lesions found. The women without femoral involvement had a mean of 4.2 lesions per patient. The women with femoral involvement had a mean of 13.6 lesions per patient. Clearly femoral involvement is