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July 29, 1974

Dipyridamole for Proteinuria Suppression: Use in a Patient With Proliferative Glomerulonephritis

Author Affiliations

From the Department of Internal Medicine, School of Medicine, Keio University, Tokyo.

JAMA. 1974;229(5):557-558. doi:10.1001/jama.1974.03230430049028

DIPYRIDAMOLE is said to reduce platelet adhesiveness and thrombus formation1 and to be effective in preventing glomerular lesions when used in combination with anticoagulants.2 We tested it alone in a patient with proliferative glomerulonephritis and found that it corrected proteinuria.

Report of a Case  A 17-year-old boy was admitted to the hospital because of proteinuria and hematuria on Feb 29, 1972. He had been well until about three months before, when he had proteinuria (1 + ) at the time of periodical examination. A month before admission he caught a cold. Several weeks later he noticed hematuria and visited the hospital. He denied having had recurrent tonsillitis. The temperature was 36.0 C (96.8 F) and the pulse rate was 72 beats per minute. The blood pressure was 120/70 mm Hg. Results of physical examination were normal.The urine gave 3+ test for protein; the sediment contained abundant red blood cells (RBCs)