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October 17, 1977

Medical News

JAMA. 1977;238(16):1713-1718. doi:10.1001/jama.1977.03280170007001

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Progress report on reevaluation of 'GRAS' food ingredients  The status—in terms of federal regulation—of approximately one in five food ingredients that are "generally recognized as safe" (GRAS) will be changed if the Food and Drug Administration (FDA) concurs with a reevaluation by a committee of experts.Seventy-two reports covering 264 GRAS food ingredients are involved so far. They are among 360 food substances being reviewed by the Life Sciences Research Office, Federation of American Societies for Experimental Biology (FASEB), Bethesda, Md, under contract with the FDA.These GRAS food ingredients are among more than 600 substances that were exempted from a 1958 amendment to the Food, Drug, and Cosmetic Act. The amendment required the FDA to rule on the safety of food additives; the 600 substances were exempted because they already were in use and "generally recognized as safe."Eventually, the FASEB committee will have reviewed more than 400