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Article
August 5, 1974

Malignant Melanoma Metastatic to the Bladder: Regression Following Intratumor Injection of BCG Vaccine

Author Affiliations

From the divisions of oncology (Drs. Silverstein and Morton) and urology (Dr. deKernion), Department of Surgery, University of California School of Medicine, Los Angeles, and the Department of Surgical Services, Sepulveda Veterans Administration Hospital, Sepulveda, Calif.

JAMA. 1974;229(6):688. doi:10.1001/jama.1974.03230440046032
Abstract

CLINICALLY recognized malignant melanoma of the urinary bladder is rare, having occurred only twice in more than 1,200 patients with melanoma seen at Memorial Hospital, New York, between 1935 and 1963.1

This report presents a case of melanoma metastatic to the urinary bladder in an immunocompetent patient without evidence of other metastatic foci. Successful treatment was achieved by intralesional injection of Galaxo-strain BCG vaccine. To our knowledge, this is the first reported case of transurethral intralesional immunotherapy.

Report of a Case  In January 1973, a 56-year-old white man underwent axillary node dissection. Twenty-one of 32 lymph nodes contained melanoma (no primary was found). Postoperatively, he received weekly immunotherapy with BCG vaccine plus an allogenic tumor-cell vaccine and became PPD tuberculin-positive on this regimen.He remained free of disease until August 1973 when painless hematuria developed. Cystoscopic examination showed no abnormalities except for a black, discrete, round, 2-cm tumor mass

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