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October 24, 1977

Harry Goldblatt: 1891-1977

JAMA. 1977;238(17):1846. doi:10.1001/jama.1977.03280180050028

The recent death of Harry Goldblatt bids us to pause and reflect on the affairs of men. The Nobel Prize committee is likely to continue its policy of not asking me for suggestions but I, unabashed, offer Dr Goldblatt's name. The experiment that gave rise to the eponymic kidney is well known, but his reasons for clamping the renal artery and the unexpected consequences may bear a brief retelling.

Goldblatt's passion was to find the cause of essential hypertension. As a young pathologist, he was greatly taken with the thought that nephrosclerosis is a primary disease that leads to hypertension. His problem was that the experimental production of nephrosclerosis in a normotensive animal is impossible, but there might be an analogy between the kidney with nephrosclerosis and a kidney with a tiny clamp on each afferent arteriole. He wondered if partially occluding both main renal arteries with large clamps would