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August 19, 1974

Staphylococcal Susceptibility to Penicillin G: The Changing Pattern Among Community Strains

Author Affiliations

From the Microbiology Section (Drs. Ross, Khan, and Controni) and the Department of Infectious Diseases (Dr. Rodriguez), Research Foundation of Children's Hospital National Medical Center, and the Department of Child Health and Development, George Washington School of Medicine (Dr. Ross), Washington, DC. Dr. Rodriguez is a recipient of MARC Faculty Fellowship H 1F 14 GM 5-6044-01 from the National Institutes of Health.

JAMA. 1974;229(8):1075-1077. doi:10.1001/jama.1974.03230460025014

Heretofore, penicillin has been considered adequate therapy for most soft-tissue infections due to Staphylococcus aureus occurring outside the hospital. One hundred thirty-three S aureus isolates obtained from children seen in the outpatient department and private practice were tested for resistance to penicillin G. The overall resistance to penicillin G by the Kirby-Bauer method was 84% for community strains compared to 95% for hospital strains. A survey of 309 healthy school children under 10 years of age showed that 47% harbored S aureus in their nares, of which approximately 68% were resistant to penicillin G. These findings suggest a trend of increasing penicillin G resistance of community (street) strains of S aureus similar to that already observed among hospital strains.

(JAMA 229:1075-1077, 1974)