Heretofore, penicillin has been considered adequate therapy for most soft-tissue infections due to Staphylococcus aureus occurring outside the hospital. One hundred thirty-three S aureus isolates obtained from children seen in the outpatient department and private practice were tested for resistance to penicillin G. The overall resistance to penicillin G by the Kirby-Bauer method was 84% for community strains compared to 95% for hospital strains. A survey of 309 healthy school children under 10 years of age showed that 47% harbored S aureus in their nares, of which approximately 68% were resistant to penicillin G. These findings suggest a trend of increasing penicillin G resistance of community (street) strains of S aureus similar to that already observed among hospital strains.
(JAMA 229:1075-1077, 1974)
Ross S, Rodriguez W, Controni G, Khan W. Staphylococcal Susceptibility to Penicillin G: The Changing Pattern Among Community Strains. JAMA. 1974;229(8):1075–1077. doi:10.1001/jama.1974.03230460025014
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