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August 19, 1974

The Glomerulopathy of Congenital Syphilis: A Curable Immune-Deposit Disease

Author Affiliations

From the departments of medicine (Drs. Lange and Tresser) and pediatrics (Drs. Yuceoglu, Sagel, and Wasserman), New York Medical College, New York.

JAMA. 1974;229(8):1085-1089. doi:10.1001/jama.1974.03230460035018

Renal complications were found in three infants, aged 2 to 3 months, who had clinical and laboratory evidence of congenital syphilis. Studies of kidney biopsy specimens identified the renal lesion as an immune glomerulopathy by the presence of coarse granular deposition of IgG and β1C on the glomerular basement membrane. On electron microscopic examination, this identification was supported by the presence of subepithelial and intramembranous electron-dense deposits. A therapeutic course of penicillin resulted in resolution of both clinical manifestations and abnormal laboratory findings. Renal biopsies were performed on two of the three infants at intervals of three and six months after completion of therapy. At that time, all findings, including immunohistologic, were normal.

(JAMA 229:1085-1089, 1974)