On July 1, 1971, a Colorado law went into effect requiring a serologic test for rubella of each female marriage license applicant. During the first 18 months, 22,785 sera were processed; of these, 3,281 (14.4%) were negative (hemagglutination inhibition titer, <10). The results provide an ongoing indicator of the immunity levels of Colorado women entering their childbearing years.
Only 248 of 878 women reported to be seronegative during June and July 1972 could be located after marriage. Of 230 women who completed questionnaires, 95 (41%) had been immunized. Of 135 women not immunized, 39 (29%) had made plans to do so, 28 (21%) were pregnant, 34 (25%) were either sterile, using contraceptives, or otherwise avoiding pregnancy, and 34 (25%) gave other responses.
(JAMA 229:1200-1202, 1974)
Judson FN, Shaw BS, Vernon TM. Mandatory Premarital Rubella Serologic Testing in Colorado: A Preliminary Report. JAMA. 1974;229(9):1200–1202. doi:10.1001/jama.1974.03230470042021
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