[Skip to Content]
[Skip to Content Landing]
November 14, 1977

Treatment of Toxemia of Pregnancy

JAMA. 1977;238(20):2143-2144. doi:10.1001/jama.1977.03280210035009

To the Editor.—  In the recent communication by Keith (237:1570, 1977), once again the spectre of the use of diazoxide in the treatment of hypertension associated with pregnancy has been raised. Several misconceptions regarding the nature of toxemia in pregnancy have led the author to conclude that occasions may arise in which the use of diazoxide may be justifiable. In a recent communication1 we have outlined several objections to the use of diazoxide in hypertensive conditions associated with pregnancy and would wish to acquaint those who might have been persuaded by Keith's suggestions regarding these potential problems.The author himself comments that there is the risk of a sudden drop in blood pressure associated with the use of diazoxide. This risk is a clear and present danger to the fetus, which is already severely compromised by restricted uterine perfusion. It is the majority opinion of those obstetrician-gynecologists who are knowledgeable