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November 14, 1977

Slow Virus Infections of the Central Nervous System: Investigational Approaches to Etiology and Pathogenesis of These Diseases

Author Affiliations

University of Colorado Medical Center Denver

JAMA. 1977;238(20):2197. doi:10.1001/jama.1977.03280210089039

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


This excellent volume, derived from a workshop held at the University of Würzburg in March 1975 summarizes investigational approaches to the etiology and pathogenesis of human and animal slow virus diseases. Topics covered include unconventional agents, such as those associated with scrapie, kuru, and Creutzfeldt-Jakob disease, and conventional agents, including those related to progressive multifocal leukoencephalopathy and subacute sclerosing panencephalitis. Approximately one fourth of the book is devoted to multiple sclerosis. Leaders in the field of biologic investigations but not engaged in slow virus research participated in a final critique.

This is not the book with which to begin a study of this rapidly expanding field, for the experts at this conference spoke to each other in great and complex detail. However, for the reader with an average background in neurology or infectious disease, the delineation of past and present approaches designed to clarify these slowly transmissible disorders, blended with