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November 21, 1977

Marrow Examination

JAMA. 1977;238(21):2263. doi:10.1001/jama.1977.03280220031006

To the Editor.—  The case report "Chlorpropamide-Induced Agranulocytosis" (238:422, 1977) contains a deficiency. Description of hypocellular marrow on bone marrow aspiration, with a photograph (Fig 2) of marrow diluted by peripheral blood, hardly documents "a marked reduction in the myeloid series." The necessity of marrow sectioning in assessing aplasia is well known,1 and the techniques and advantages of marrow coring are well described.2 Marrow aplasia as a cause for inadequate marrow aspiration is far less common in our experience than lymphoma, hairy cell disease, fibrosis, or replacement by tumor.