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November 21, 1977

Reversal of Central Anticholinergic Syndrome by Galanthamine

JAMA. 1977;238(21):2293-2294. doi:10.1001/jama.1977.03280220061024

Ten volunteers were given 2 mg scopolamine intravenously (IV) to produce substantial drowsiness and sleepiness. Galanthamine, 0.5 mg/kg IV, effectively reversed the central anticholinergic syndrome produced by scopolamine. Electroencephalographic monitoring of two subjects matched the observed changes of consciousness: scopolamine replaced the dominant awake alpha rhythm with a disorganized, slow, 4- to 6-Hz activity. Galanthamine promptly returned the EEG pattern to the control, awake state.

Galanthamine produces effective, safe, and long-lasting reversal of the central anticholinergic syndrome in man.

(JAMA 238:2293-2294, 1977)