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November 21, 1977

Reversal of Central Anticholinergic Syndrome by Galanthamine

Author Affiliations

From the Departments of Anesthesiology (Dr Baraka) and Neurology (Dr Harik), American University of Beirut, Beirut, Lebanon.

JAMA. 1977;238(21):2293-2294. doi:10.1001/jama.1977.03280220061024

Ten volunteers were given 2 mg scopolamine intravenously (IV) to produce substantial drowsiness and sleepiness. Galanthamine, 0.5 mg/kg IV, effectively reversed the central anticholinergic syndrome produced by scopolamine. Electroencephalographic monitoring of two subjects matched the observed changes of consciousness: scopolamine replaced the dominant awake alpha rhythm with a disorganized, slow, 4- to 6-Hz activity. Galanthamine promptly returned the EEG pattern to the control, awake state.

Galanthamine produces effective, safe, and long-lasting reversal of the central anticholinergic syndrome in man.

(JAMA 238:2293-2294, 1977)