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September 21, 1970

Congenital Absence of the Ductus Deferens

JAMA. 1970;213(12):2080. doi:10.1001/jama.1970.03170380054020

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To the Editor.—  It is the rule rather than the exception, as stated in the answer, to have a normal testicle associated with a congenital absence of the vas deferens on the same side, and to have bilateral normal testicles if the absence of the vas deferens is bilateral. The embryologic development of the testes is from the genital ridges on the medial aspect of the mesonephros, while the vas deferens has a different origin, from the mesonephric duct. If development is disturbed before the human embryo is at the 60 mm (13 weeks) stage, it is possible to have a fully developed testicle and globus major of the epididymis with an undeveloped vas deferens, seminal vesicle, and ejaculatory duct. If the mesonephric duct ceased development at a very early stage (four weeks) the ureteric bud would not develop and there would be an absence of the ureter and kidney